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New insights on tau protein aggregation and the spreading of tau pathology in Alzheimer's disease
Pribiš, Matej ; Růžička, Jiří (advisor) ; Telenský, Petr (referee)
More than 100 years have passed since the original description of a "peculiar" disease of cerebral cortex by Dr. Alzheimer. Lots of discoveries on this disease and its cellular and molecular correlates has been done since then, the disease, however, up to this day resists most of the causal attempts of treatment. The major component of silver stained tangled bundles of fibrils that Alzheimer observed under his microscope has been identified as a microtubule associated protein tau and it has been shown to be a crucial part of many other neurodegenerative disorders, which were collectively named tauopathies. However, even after such a long time, the exact role of tau in neuronal physiology and pathology remains rather obscure. According to the latest research, it even seems that some of the widely accepted truths might require more closer observation and validation. The aim of this thesis is to sum up and clarify the important aspects of the mechanism of tau aggregation, the basic factors that influence it and its transcellular movement as a mechanism of pathology spreading. Keywords: aggregation, pathology spreading, tauopathy, Tau protein iii
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